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FXR is a very important receptor, part of a negative feedback in the liver, whereby the binding of bile salts, especially chenodeoxycholic acid, represses the de-novo synthesis of bile salts (352, 353)

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Under isoflurane anesthesia, a small laparotomy was performed, and 80% of the stomach (along the greater curvature and fundus) was excised in the VSG group using microvessel clips, followed by hand-sewn sutures